Research

Evolutionary Biology

 

Evolutionary and comparative physiology

 

Molecular evolution, color vision, wing color, behavior

 

Molecular Evolution of Pathogens

 

Functional and evolutionary genomics: gene regulation and evolution of eukrayotic sex chromosomes
 
Evolutionary genetics, host-parasite interactions, development of mathematical, computational and conceptual models to study complex phenotypes

 

population genetics, molecular evolution, genome evolution

 

Quantitative and population genetics, genetic basis of quantitative variation for different phenotypes in different organisms, gene mapping and microarray analysis

 

Microbiology, Environmental Genomics, Oceanography

 

Applications of genomics, computation, and sequencing technologies to the analysis of transcriptional regulation in development. Emphasis on long-range protein-DNA interactions, ChIP-seq, RNA-seq, ChIA-PET, and comparative genomics

 

Structural evolutionary genomics and evolution of the expression network

 

Genome evolution, gene duplication, population genetics, adaptation

 

Mathematical and Computational Biology, Theoretical Biology, infectious diseases and the immune system, carcinogenesis & cancer treatment

Developmental Biology

 

Drosophila development, TGF-beta signal transduction, cell signaling

 

Molecular embryology, molecular biology, developmental biology, functional genomics, endocrinology, pharmacology, high-throughput screening

 

Regulation of neurogenesis and neural differentiation; systems biology of stem cells and human developmental disorders

 

Growth factor signaling and functional genomics in Xenopus and zebrafish, stem cell research and diabetes, Bioinformatics and functional genomics, Veterbrate embryology and growth factor signaling

 

Systems biology of cell differentiation. Using a combination of theoretical and experimental approaches to find out how regulatory networks control the progression from a stem cell state to a differentiated state.

 

Effect of exercise on gene and protein expression of key inflammatory and growth mediators in peripheral blood mononuclear cells in health children

 

Limb regeneration; dedifferentiation; pattern formation

 

Cardiovascular modeling: development and function at the cellular, tissue and organ level
 
Molecular basis of genetic diseases in humans

 

Systems biology of morphogenesis and pattern formation, growth control, proteoglycans, extracellular matrix, birth defects syndromes

 

Regulation of growth factor signaling in patterning, regeneration, and oncogenesis, Mechanisms of late onset neurodegeneration

 

Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Bio-Medical Informatics / Computational Biology / Systems Biology / Scientific Inference Systems / Mathematical Methods

 

Applications of genomics, computation, and sequencing technologies to the analysis of transcriptional regulation in development. Emphasis on long-range protein-DNA interactions, ChIP-seq, RNA-seq, ChIA-PET, and comparative genomics
 
       Medha Pathak
       Mechanobiology of neural stem cells; How cells transduce mechanical forces; Mechanically-activated ion channels; Role of Piezo1 in neural stem cell fate; Mechanical forces in neural development.
 
Stem cells and stem cell niche, regeneration of tissues and organs, biological pattern formation, self-organization, skin and hair follicles, adipose tissue, WNT and BMP signaling pathways
 
Zebrafish development, pattern formation, morphogenesis

 

Genetic and epigenetic programing; functions of long range non-coding RNAs

 

Drosophila development, regulation of nuclear position and migration, effects of proteoglycans in growth factor signaling, regulation of developmental gene expression.
 
Experimental and computational approaches to studying the regulation of gene expression, Drosophila development, interpreting natural variation in regulatory sequences

Computational Biology

 

Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Large-Scale Data Analysis: Information Access & Management / Computational Biology /
Bioinformatics / Systems Biology

 

Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining
Bio-Medical Informatics / Computational Biology

 

Large-Scale Data Analysis: Information Access & Management / Databases / Information Infrastructure / Bio-Medical Informatics / Computational Biology

 

Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining

 

Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Bio-Medical Informatics / Computational Biology / Protein Structure Prediction / Drug Discovery / Genetic Regulation

      

       Devon Lawson
       Cancer, metastasis, intratumor heterogeneity, single-cell omics, metastatic evolution

 
Computational Biology, Protein Structure, Protein Function

 

Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Bio-Medical Informatics / Computational Biology / Systems Biology / Scientific Inference Systems / Mathematical Methods

 

Applications of genomics, computation, and sequencing technologies to the analysis of transcriptional regulation in development. Emphasis on long-range protein-DNA interactions, ChIP-seq, RNA-seq, ChIA-PET, and comparative genomics

 

Adaptive biomedical signal processing, control algorithms for biomedical devices, brain-machine interfaces, modeling and analysis of biological neural networks

 

Computational Biology, Developmental and Cell Biology, Numerical Analsis, Interface Dynamics in Materials and Fluids, High-Performance Computing, Modeling and Simulation of Tissue Patterning, Systems Biology

 

Database Systems, Object-Oriented Systems, Parallel Processing, Simulation, Interactive Multimedia Systems. Biomedical Database Management, Intranet/Internet Technologies

 

Artificial Intelligence; Large Scale Data Analysis; Statistics

 

Mathematical modeling and computational methods; Monte Carlo methods; computational biophotonics; radiative transport and diffusion processes; biomedical optics

 

Machine Learning and Intelligent Systems

 

Low Cost DNA Sequencing, Single Cell Omics, Microscopy and Spectroscopy on the Nanoscale

 

Computational Biology, Bioinformatics, Genomics, Neural Computation, and Machine Learning

Chemical Biology

 

Transcriptional regulation in normal and diseased epithelia

 

Interface of structural molecular biology and physical chemistry

 

Role of the regulatory proteins Ovo in germ cell and epidermal differentiation

 

3D tissue modeling, angiogenesis, tumor microenvironment

 

Self-assembly of biological and biomimetic nanoscale materials based on amino acids and on nucleic acids using computational and theoretical methods

 

Control of the cell cycle through mechanisms involving ubiquitination

 

MAP kinase mediated signal transduction; dimorphic regulation in yeast

 

Theoretical Chemistry, Chemical Physics

 

Theoretical studies of ultrafast dynamics and relaxation processes of large molecules, biological complexes, and semiconductors; Nonlinear ultrafast spectroscopy

 

Molecular mobility in biological materials, vibrational coherences, ultrafast microscopy

 

Chemical biology, molecular imaging, organic chemistry, immunology, bioorthogonal chemistry, post-translational modifications
 
Computional and modeling approaches to the study of immune system dynamics and regulation
 
 
Molecular genetics and biochemistry of retrotransposons and metabolic engineering in budding yeast

 

Molecular biology of Hydra development

 

Computational Chemistry, Biophysical Chemistry, Atmospheric Chemistry

 

Biochemistry, Chemical Biology, Structural Biology, Microbiology

 

Bioorganic chemistry, chemical biology, protein engineering, molecular biology and biochemistry

 

Mechanism and regulation of chromosome structural changes required for the maintenance of genome integrity

Cell Biology

 

Use of molecular biology, biochemistry, genetics, cell biology and math/computation to study fundamental questions of cell signaling and regulation

 

Design of new fluorescence instruments, protein dynamics, hydration of proteins, and I.R. spectroscopy of biological substances

 

Biophysics of molecular motors and intracellular transport

 

Biological mass spectrometry/proteomics, ubiquitin-proteasome degradation pathways, protein complexes, posttranslational modifications, protein-protein interaction

 

Cell cycle and molecular genetics studies of breast cancer
 
 
       Medha Pathak
       Mechanobiology of neural stem cells; How cells transduce mechanical forces; Mechanically-activated ion channels; Role of Piezo1 in neural stem cell fate; Mechanical forces in neural development.
 
Intracellular organization, geometry of organelles (size, shape, position, dynamics), mitochondrial networks
2011 Recent News. Copyright © 2013. The Center for Complex Biological Systems, UC Irvine
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