We are pleased to annouce Dr. Robert Quinn from the Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, as our invited guest speaker for this month's Metabolomics Interest Group (MIG) meeting.
Dr. Quinn will be speaking on "Visualizing the Chemical World of Mucosal Associated Microbial Communities with Molecular Networks" using examples of microbial metabolomics data from coral reefs and human lung samples, and showcasing the GNPS (Global Natural Products Social Molecular Networking) initiative.
Wednesday, June 17th @ 12:00 -1:00 pm,
BioSci III, Rm 2120 (conference room)
Light refreshments will be served.
Abstract: Mucosal associated microbial communities exist in all biological environments from coral reefs to human lungs. They are comprised of host epithelial cells coated in mucus and harboring a symbiotic microbial community. These systems are highly diverse and contain myriad competitive and cooperative interactions. Dysbioses is an important phenomenon in these systems, where shifts in the constituent microbial communities are associated with a diseased state. While the taxonomic and functional genetics of these communities has been characterized in a number of studies, the global chemistry of these environments is poorly uncharacterized. Mass spectrometry based metabolomics has lagged behind progress in sequencing based omics because of the paucity of sufficient searchable databases. Since the advent of the novel MS/MS data analysis algorithm ‘molecular networking’ the knowledge gap between sequence and metabolite is beginning to narrow. We have applied mass spectrometry based metabolomics to two very different, mucosal associated microbial communities, the cystic fibrosis lung and the reef building coral. The molecular networking approach has revealed that although separated by 500 million years of evolution and thought of as very different systems, the chemistry and physiology that governs these two environments contains much similarity. This lecture will describe the preliminary findings of our foray into the chemical world of these complex systems.