Employment Opportunities

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Epigenomic Mechanisms of Memory Disruption by Early-life Seizures

November, 2018: A postdoctoral position is offered in a vibrant Neuroscience laboratory to probe the transcriptional and epigenetic mechanisms initiated by early-life seizures that differentially program newborn and mature hippocampal dentate gyrus granule cells and pyramidal neurons. These changes cause significant disruption of hippocampus-dependent memory processes associated with Epilepsy, with major clinical importance.
The NIH-funded project will employ innovative methodologies to examine, at single cell resolution, the role of specific transcription factors in functional and structural hippocampus-dependent memory processes associated with Epilepsy, with major clinical importance. The NIH-funded project will employ innovative methodologies to examine, at single cell resolution, the role of specific transcription factors in functional and structural hippocampal derangements that promote memory problems. . Single-cell RNA-seq, as well as ChIP-seq, and interventional approaches will be employed. Additional methods used in the lab include DREADD technology, live 2-photon imaging, as well as DTI imaging and behavioral testing.  (See: Patterson et al., J Neurosci, 2017;, McClelland et al., eLife 2014; Singh-Taylor et al., Molec Psych 2018; Bolton et al., Biol Psych 2018; Dube et al., Trends Neurosci, 2007).

The laboratory is located on the UC Irvine campus, a rich, diverse community of Molecular and Neuroscience research within Southern California.
Candidates should have a recent PhD degree and experience in Molecular Biology, and must be highly motivated. Experience in Bioinformatics and Neuroscience is desirable.

Please send a CV, a brief statement of research accomplishments and interests, and a list of references to baramlab@uci.edu.
Tallie Z. Baram, MD, PhD
D.D. Shepard Professor of Neurological Sciences
Prof. Pediatrics, Anatomy/ Neurobiology, Neurology
University of California-Irvine, CA, USA

 

 Open Postdoctoral Scholar Position - To Investigate the Polygenic Basis of Congenital Heart Defects

March, 2018 - The UC Irvine Center for Complex Biological Systems seeks a postdoctoral scholar to study the polygenic basis of congenital heart defects, and the transcriptional identity of heart stem/progenitor cells, in mouse models of mammalian heart development.  The position is fully funded and will be supervised by Professors Anne Calof and Arthur Lander.   Research will focus on how multiple small perturbations to gene expression collectively produce heart defects in multi-system birth defects disorders known as transcriptomopathies.

The successful applicant will have a Ph.D. in molecular and/or developmental biology, genetics, or genomics, and evidence of publication and/or preparation of high quality journal article(s). The applicant’s training should provide sufficient preparation to use mouse genetics, embryology, molecular biology, high resolution optical imaging (including optical projection tomography and MRI), together with genomics (RNA sequencing/bioinformatics), to identify morphogenetic abnormalities (progenitor cell proliferation, patterning and migration) and gene expression changes. Single-cell RNA sequencing of early embryos will also be used to identify transcriptional changes in individual progenitor cells.

The salary range for this position is negotiable and will be commensurate with training and experience; healthcare benefits are included.  Appointment will initially be for a one-year period with extension for up to 4 years, subject to performance.

Please send inquiries about this position to:

Anne L. Calof, Professor, CCBS (alcalof@uci.edu)

Arthur D. Lander, Professor and Director, CCBS (adlander@uci.edu)

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

 

 

Postdoctoral Scholar, Project Scientist and Specialist Positions 

      • Postdoctoral Scholar, Project Scientist and Specialist positions are occasionally available throughout the year in The Center for Complex Biological Systems, at the University of California, Irvine.
      • Initial appointment would be for a one-year period, with the possibility of extension, dependant in part on continuing extramural funding availability.
      • Current projects are focused on how biological systems in model organisms process spatial information during development, intracellular signaling, and cell proliferation. Other efforts within the Center include the development of computational and optical tools needed for measuring and modeling spatially dynamic systems and fluorescence spectroscopy and microscopy methods.

Please refer to the UCI Academic Employment website for current positions available within the Center, and other academic units at UC Irvine.

 

 The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

 
 
 

 

 

2011 Employment Opportunities. Copyright © 2013. The Center for Complex Biological Systems, UC Irvine
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