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January 2021

CMCF Seminar

January 11, 2021 @ 2:00 pm - 3:00 pm
Zoom, ID: 989 9312 3840

Speaker: Jan-Christian Hütter, Broad Institute MIT Title: Inference of gene expression trajectories and statistical optimal transport. Single-cell RNA sequencing (scRNA-seq) enables the collection of rich phenotypic information of individual cells. During this sequencing process, each cell is destroyed, which poses challenges in the analysis of time-course data of heterogeneous populations since cell trajectories need to be computationally inferred. Standard trajectory inference methods approximate the transcriptional spectrum of all time points combined by a graph, not leveraging information about the time-points…

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CMCF Seminar

January 12, 2021 @ 2:00 pm - 3:00 pm
Zoom, ID: 989 9312 3840

Speaker: Zixuan Cang, UCI Title: Topological and Geometric Data Analysis Meets Data-driven Biology Topological and geometric data analysis (TGDA) is a powerful framework for quantitative description and simplification of datasets' shapes. It is especially suitable for modern biological data that are intrinsically complex and high-dimensional. Traditional topological data analysis considers the geometric features of a dataset, while in practice, there could be both geometric and non-geometric features. In this talk, I will introduce a persistent cohomology based method, enriched barcode…

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CMCF Seminar

January 13, 2021 @ 2:00 pm - 3:00 pm
Zoom, ID: 989 9312 3840

Speaker: Christopher Miles, NYU Title: Modeling & data science of stochastic organization in the mitotic spindle For cells to divide, they must undergo mitosis: the process of spatially organizing their copied DNA (chromosomes) to precise locations in the cell. This procedure is carried out by stochastic components that manage to accomplish the task with astonishing speed and accuracy. Recent experimental advances from collaborators with NY State Department of Health provide 3D spatial trajectories of every chromosome in a cell during…

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Biophysics and Systems Biology Seminar Series

January 14, 2021 @ 10:00 am - 11:00 am
Zoom – RIP, ID: 913 6442 7728

Speaker: Dr. Zheng Shi (Rutgers University, Department of Chemistry and Chemical Biology) Host: Dr. Medha Pathak

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Dev & Cell Bio Seminar Series – Winter 2021

January 14, 2021 @ 11:00 am - 12:00 pm

Speaker: Irene Chiolo, USC Department of Biological Sciences Title: “Highways for Repair: Nuclear Actin Filaments and Myosins Drive Relocalization and Repair of Heterochromatic DNA Breaks” Zoom Link: https://uci.zoom.us/j/92890139888?pwd=WGxOM1hqbmhoVDcxS3hGQWljR0w0Zz09

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CMCF Seminar

January 14, 2021 @ 2:00 pm - 3:00 pm
Zoom, ID: 989 9312 3840

Speaker: Alexandria Volkening, Northwestern Univiersity Title: Modeling and analysis of zebrafish-skin patterns Many natural and social phenomena involve individual agents coming together to create group dynamics, whether they are cells in a skin pattern, voters in an election, or pedestrians in a crowded room. Here I will focus on the example of pattern formation in zebrafish, which are named for the dark and light stripes that appear on their bodies and fins. Mutant zebrafish, on the other hand, feature different…

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CMCF Seminar

January 15, 2021 @ 2:00 pm - 3:00 pm
Zoom, ID: 989 9312 3840

Speaker: William Gilpin, Harvard Quantitative Biology Initiative Title: Chaos and emergent computation in biological dynamics Experimental measurements of biological systems often have a limited number of independent channels, hindering the construction of interpretable models of living processes. Dynamical systems theory provides a rich set of tools for inferring underlying mathematical structure from partial observations, yet translating these insights to real-world biological datasets remains challenging. In this talk, I will overview my recent work at the intersection of nonlinear dynamics, chaos, and biology.…

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Dev & Cell Bio Seminar Series – Winter 2021

January 21, 2021 @ 11:00 am - 12:00 pm

Speaker: Travis Wiles, UC Irvine- Molecular Bio & Biochemistry Title: Exploring the Form & Function of the Intestinal Ecosystem Zoom Link: https://uci.zoom.us/j/93834212862?pwd=Mms4cFlURmNtRk1xWHhwMzNPOCtvZz09

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Focus on Evolution

January 26, 2021 @ 4:00 pm - 5:00 pm
Zoom – Foe

Speaker: Yuheng Huang (PI: Grace Lee) Title: Host chromatin environment shapes the evolutionary dynamics of transposons

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February 2021

Focus on Evolution

February 9, 2021 @ 4:00 pm - 5:00 pm
Zoom – Foe

Speaker: Rob Linger (PI: Tony Long) Title: The contributions of standing variation and recombination to long-term evolution of budding yeast

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